Developmental Regulation of Genomic Imprinting during Gametogenesis
نویسندگان
چکیده
منابع مشابه
Regulation and Flexibility of Genomic Imprinting during Seed Development W
Genomic imprinting results in monoallelic gene expression in a parent-of-origin–dependent manner. It is achieved by the differential epigenetic marking of parental alleles. Over the past decade, studies in the model systems Arabidopsis thaliana and maize (Zea mays) have shown a strong correlation between silent or active states with epigenetic marks, such as DNA methylation and histone modifica...
متن کاملRegulation and flexibility of genomic imprinting during seed development.
Genomic imprinting results in monoallelic gene expression in a parent-of-origin-dependent manner. It is achieved by the differential epigenetic marking of parental alleles. Over the past decade, studies in the model systems Arabidopsis thaliana and maize (Zea mays) have shown a strong correlation between silent or active states with epigenetic marks, such as DNA methylation and histone modifica...
متن کاملRegulation of alternative polyadenylation by genomic imprinting.
Maternally and paternally derived alleles can utilize different promoters, but allele-specific differences in cotranscriptional processes have not been reported. We show that alternative polyadenylation sites at a novel murine imprinted gene (H13) are utilized in an allele-specific manner. A differentially methylated CpG island separates polyA sites utilized on maternal and paternal alleles, an...
متن کاملDevelopmental Regulation of Genomic Imprinting of the IGF2 Gene in Human Liver1
of the germ lines. Previous data have suggested that in nonmalignant tissues an imprint is constant throughout life and is not susceptible to modification, except during gametogenesis. The present study examines allelic expression of the IGF2 gene in human liver during postnatal development. The data show that the IGF2 gene is imprinted (i.e., monoallelically expressed) in liver at the age of 6...
متن کاملDevelopmental regulation of genomic imprinting of the IGF2 gene in human liver.
Control of the expression of the human insulin-like growth factor II gene is known to be complex, displaying both tissue-specific and developmental regulation. Insulin-like growth factor II is expressed at high levels in most tissues in the human fetus and appears to be important in fetal growth. In adult life, high levels of expression are found chiefly in liver, kidney, skin, nerve, and muscl...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1995
ISSN: 0012-1606
DOI: 10.1006/dbio.1995.0021